Research Interest:
The daunting challenge in the era of
Proteomics is to identify the functions of all the proteins identified by the
Genomic Project and to elucidate the interplay among these proteins in
governing the normal activities of organisms. One approach is to define the
structural motifs of these proteins. However, a meaningful structure-function
correlation depends on an understanding of the unique properties associated
with these structural motifs. We are studying two motifs, namely, the TIM
barrel which is the basic motif of hundreds of enzymes and the helix-turn-helix
motif adopted by many DNA binding proteins. The approaches are biophysical
solution chemistry in conjunction with structural biology and molecular
biology.