Vol43 No.9: 663-670

mRNA trafficking and local translation: the Yin and Yang of regulating mRNA localization in neurons

John R. Sinnamon¹ and Kevin Czaplinski^2*

(1Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794, USA; 2 Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA)

Abstract
����Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites and axons, axon path-finding, and synaptic plasticity. We provide a brief review on the regulation of localizing mRNA in mammalian neurons through critical post-translational modifications of the factors involved. These examples highlight the relationship between mRNA trafficking and the translational regulation of trafficked mRNAs and provide insight into how extracellular signals target these events during signal transduction.

Received: 2011-2-23����Accepted: 2011-4-27

*Corresponding author . Tel: +1-631-632-8635; Fax: +1-631-632-8575; E-mail: [email protected]

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