Vol43 No.10: 745-756

Wnt/Ca21 signaling pathway: a brief overview

Antara De^1,2*

(1 Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064, India; 2 Present address: Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, India)

Abstract
����The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical counterpart, the Wnt/��-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca2+ signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca2+ pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca2+ signaling pathway.

Received: 2011-5-20����Accepted: 2011-7-27

*Corresponding author . Tel: +91-33-9038639153; Fax: +91-33-24146266; E-mail: [email protected]

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