Vol43 No.10: 757-762

Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases

Wenyan Xu^1,2,3, Liling Li¹, Liangcheng Du^2*, and Ninghua Tan^1*

(1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; 2 Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA 3Graduate University of Chinese Academy of Sciences, Beijing 100049, China)

Abstract
����An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.

Received: 2011-4-5����Accepted: 2011-5-19

*Corresponding author . Tel: +86-871-5223800; Fax: +86-871-5223800; E-mail: [email protected] (N.T.)/Tel: +1-402-472-2998; Fax: +1-402-472-2998; E-mail: [email protected] (L.D.)

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