Vol43 No.11: 877-883

Targeted novel surface-modified nanoparticles for interferon delivery for the treatment of hepatitis B

Namita Giri^1,2, Priti Tomar¹, Vijai Singh Karwasara¹, Ravi S. Pandey¹, and V.K. Dixit^1*

(1 Department of Pharmaceutical Sciences, Dr Hari Singh Gour Vishwavidyalaya, Sagar, MP 470003, India; 2 Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas, MO, USA)

Abstract
����The purpose of the present work was to develop hepatitis B surface antigen (HBsAg) surface-adsorbed cationic poly (d,l-lactic-co-glycolic acid) PLGA nanoparticles for interferon alpha (IFN��) delivery targeted to hepatocytes. Cationic PLGA nanoparticles loaded with IFN�� were prepared using the double emulsification technique. Delipidated HBsAg was passively adsorbed on the surface of nanoparticles by using the simple dipping and drying method. Surface morphology and size distribution of nanoparticles were analyzed by scanning electron microscopy and dynamic light-scattering method, respectively. The biodistribution behavior of plain and HBsAg-coated 99mTc-tagged PLGA nanoparticles was also examined followed by intravenous injection. The results revealed that ∼75% of the radioactivity was recovered in the liver after 4 h of injection that was nearly 3-fold greater in magnitude than the plain PLGA nanoparticles. These data demonstrated that the novel formulation of nanoparticles has potential application in hepatic-targeted drug delivery.

Received: 2011-6-2����Accepted: 2011-8-1

*Corresponding author . Tel: +91-7582-265457-126; Fax: +91-7582-2658769; E-mail: [email protected]

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